david brenner ucsd wife

Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. Hepatology. 2013 Aug; 20(8):1116-23. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. 2014 Dec; 60(6):1920-8. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. 2012 Aug; 143(2):307-20. J Biol Chem. 2017 Jun 30; 127(7):2697-2704. Gastroenterology. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. J Clin Invest. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. Development of an animal model of chronic alcohol-induced pancreatitis in the rat. Hepatology. 2018 12; 68(6):2059-2061. 2000 Dec; 32(6):1272-9. J Natl Cancer Inst. Liver Transpl Surg. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. 1997 May; 25(5):1128-35. Am J Epidemiol. 2006 Jul; 37(7):1691-6. Heterogeneity of HSCs in a Mouse Model of NASH. 1998 Aug; 115(2):443-51. 1994 Sep; 14(9):5950-60. 2010 Feb 25; 3:39-47. CCR1 and CCR5 promote hepatic fibrosis in mice. 2000; 35 Suppl 12:80-3. Am J Physiol Gastrointest Liver Physiol. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. 2003 Oct; 125(4):1009. A method for in vitro DNase I footprinting analysis on supercoiled templates. 2017 12 12; 8(1):2137. Stem Cells Cloning. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. Clin Immunol. Luedde T, Rodriguez ME, Tacke F, Xiong Y. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. 2009 Oct; 137(4):1467-1477.e5. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Clin Liver Dis. J Clin Invest. Expression of collagen genes in the liver. 1992 Jun; 50(6):1203-10. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Hepatology. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. 2022 07; 10(7):e1953. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. J Biol Chem. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. 2002 May 17; 277(20):18229-37. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. 2017 01; 65(1):78-88. J Hepatol. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. A logical approach to the patient with jaundice. Alteration of interferon-a/ receptors in chronic hepatitis B patients. 2000 Dec; 279(6):G1333-42. 1993 Apr; 264(4 Pt 1):G589-95. Nat Immunol. Dig Liver Dis. 2012 Jul; 36(1):22-9. Proc Am Thorac Soc. What's new in liver fibrosis? Proc Natl Acad Sci U S A. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. J Clin Invest. Cell Metab. 2003 Apr; 27(4):726-31. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Mol Cell Biol. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. 2001 Nov; 34(5):953-63. 2007 Jun 15; 462(2):266-72. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. 1991 Oct; 14(4 Pt 1):740-2. Nucl Med Biol. Vuori will Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. 2011 Jan 04; 108(1):308-13. Gbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schlmerich J. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. Liver Int. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? J Hepatol. Fibrogenesis Tissue Repair. Am J Pathol. 2015 Dec; 149(7):1784-93. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. Proc Natl Acad Sci U S A. 2012 Nov; 122(11):4280-2. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. 2012 Nov; 13(11):1072-82. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. 2001 May; 25(5 Suppl ISBRA):251S-253S. 2020 Nov 03; 32(5):901. Cell Metab. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. Hepatology. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. 2003 Oct; 23(5):386-96. Proc Natl Acad Sci U S A. Thomas E. Starzl: Transplantation pioneer. Am J Physiol Gastrointest Liver Physiol. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. 2001 Jan; 280(1):G139-48. Curr Opin Gastroenterol. Hepatology. 2021; 12(1):293-320. J Cell Biol. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. J Biol Chem. 2000 Jan; 118(1):90-100. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. 2016 Mar; 13(3):126-8. 1999 09; 277(3):G671-7. Mol Cell Biol. Recent advances in liver stem cell therapy. 2007 Mar; 14(3):568-75. J Hepatol. 2014 Jul 21; 5:4451. 2021; 12(3):891-920. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B. HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4- cell lines. Proc Natl Acad Sci U S A. Data from arrays: an embarrassment of riches. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Hepatol Commun. 2004 Jan; 2(1):9-13. 2020; 144(8):400-412. 2017 11; 15(11):1808-1810. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. 2017 12; 1(10):1043-1057. 2003 Feb; 124(2):445-58. 1993 May 15; 53(10 Suppl):2279-86. Note that an individual publication can be assigned to more than one field. Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells. Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. 2001 Jul 01; 167(1):173-80. 2010 Jan 12; 107(2):844-9. USC undermined our ability to do research. J Bioenerg Biomembr. Front Physiol. Am J Physiol Gastrointest Liver Physiol. J Clin Invest. 2013 Feb 01; 12(3):381-2. Surgery. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. 1998 08; 275(2):G269-78. 2022 08 02; 34(8):1201-1213.e5. Hepatic porphyrias. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. J Biol Chem. 1993 Jan; 264(1 Pt 1):G95-103. 1991 Aug; 11(8):4065-73. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. University of California San Diego named John M. Carethers as the vice chancellor for Health Sciences (VCHS), effective January 1, 2023. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. Amyotroph Lateral Scler Frontotemporal Degener. NEK1 mutations in familial amyotrophic lateral sclerosis. WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. 2006 Aug; 116(8):2058-9. Promising Therapy Candidates for Liver Fibrosis. 2000 Jun 01; 95(11):3568-77. 1999 Mar; 31(2):173-9. J Clin Gastroenterol. 2017 Apr 03; 127(4):1254-1270. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. 2017 Feb 01; 312(2):C131-C143. Age (Dordr). 1996 Nov; 271(5 Pt 1):G780-90. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. Toxicol Sci. 2003 Mar 07; 278(10):8083-90. 2005 Apr; 115(4):849-59. He will assume his new role effective September 14. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. Hepatology. 2023 Jan 17; 1-6. 1987 Dec 25; 262(36):17690-5. Proc Natl Acad Sci U S A. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. J Immunol. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Mol Cell Biol. The role of Smad3 in mediating mouse hepatic stellate cell activation. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA. Gastroenterology. Hepatology. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. 2005 Jun; 42(6):850-9. Int J Stroke. 2017 10 10; 114(41):10808-10809. Nature. 2014 Jul; 124(7):2921-34. 2016; 7:47. J Clin Invest. 2009 Jan 16; 378(3):348-53. Hepatology. Blood. 2014 Oct 28; 83(18):1653-60. 2004 Jun; 40(6):942-51. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. 2006 Sep; 45(3):429-38. 2012 Sep; 143(3):765-776.e3. 2016 Sep; 92(3):84-92. 2002 Dec; 36(6):1498-508. Transplantation. 2018 09; 68(3):1070-1086. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Cell Metab. 2021 09; 191(9):1564-1579. Gastroenterology. 1998 Jun; 42(6):779-87. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. He replaces David A. Brenner as vice chancellor for Health Sciences, who stepped down on July 1, 2022. Akt activation protects rat liver from ischemia/reperfusion injury. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. 2007 Apr-Jun; 6(2):83-8. 2015 Apr; 61(4):1239-50. Am J Physiol Cell Physiol. 2008 Nov; 48(5):1420-9. This graph shows the total number of publications by year. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. 1992 Feb 28; 183(1):184-92. Hepatology. 2005 May; 41(5):1085-95. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. 1999; 8(3):151-63. Cell Cycle. 2013 Sep 16; 202(6):951-66. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. 1994 Jun 21; 91(13):6030-4. Stroke. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH. 2004 Oct; 127(4):1260-2. 2000 Feb; 31(2):391-8. 2012 Dec; 56(6):2316-27. NK and NKT cells in liver injury and fibrosis. Dig Dis Sci. 2008 Feb; 233(2):109-22. J Hepatol. Cancer Res. 2005 Feb; 115(2):209-18. 2010 Feb; 16(2):181-90. Nature. Moderate alcohol drinking: effects on the heart and liver. J Bone Miner Res. 2019 10; 68(10):1884-1892. 1989 Jun 05; 264(16):9583-91. 1998 Jan 01; 160(1):410-8. Am J Physiol Gastrointest Liver Physiol. 2020 01; 245(2):96-108. La Jolla groups issue letter on city parks master plan. Biofactors. J Biol Chem. 2012 Mar; 27 Suppl 2:65-8. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Studies with human cultured skin fibroblasts. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. J Cardiovasc Med (Hagerstown). Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. 2018 01; 53(1):6-17. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes.

Deaths In Stockton, Ca 2021, South Carolina Baseball Stats 2022, What Does Cantaloupe Mean Sexually, Latitude Margaritaville Daytona Beach Homes For Sale By Owner, Compare Ezekiel 1 And Revelation 4, Articles D